Muscadine grapes, native to the southeastern United States, are renowned as a great source of antioxidant compounds. Muscadine grapes grew wild in wooded areas and were enjoyed for their nutritional benefits by Native Americans hundreds of years ago. They were subsequently introduced to European settlers who proceeded to cultivate the fruit. The seeds of Muscadine grapes are loaded with compounds that support health including phenolic compounds such as ellagic acid, oligomeric proanthocyanidins (OPCs), resveratrol and quercetin.* Muscadine grapes grow and thrive in the difficult, hot and humid climate of the southeastern United States, making them an especially rich source of these free radical scavenging phytochemicals.*